PBM Research109 studies

Photobiomodulation for Circulation

109 peer-reviewed studies on light therapy for circulation, spanning 1990 to 2020. Filtered from the full PBM database of 4,914 studies.

109

Total Studies

Human Studies

106

Positive Results

Wavelength Bands

Study Types

Human

38 (35%)

In vitro

35 (32%)

Rat

12 (11%)

Mouse

12 (11%)

Animal

6 (6%)

Rabbit

5 (5%)

Outcomes

positive

106 (97%)

unclear

3 (3%)

Wavelength Distribution

Red (600-700nm)

40 studies

Not specified

33 studies

Near-IR (700-900nm)

30 studies

IR (900nm+)

3 studies

Green (500-600nm)

3 studies

All Studies (109)

Microcirculatory Response to Photobiomodulation-Why Some Respond and Others Do Not: A Randomized Controlled Study.

GavishLasers Surg Med2020

positiveHuman

Proteomic analysis of plasma proteins after low-level laser therapy in rats.

KilikPhysiol Res2019830nm

positiveRat

Comparative In Vitro Study: Examining 635 nm Laser and 265 nm Ultraviolet Interaction with Blood.

ElblbesyPhotobiomodul Photomed Laser Surg2019

positiveHuman

Successful Treatment of Digital Ischemia Following a Carbon Dioxide Laser and Tourniquet for a Digital Procedure With Adjuvant Low-Level Laser Therapy.

Lueangarun & TemparkJ Lasers Med Sci2019633nm

positiveHuman

Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway.

LiMicrovasc Res2019650nm

positiveIn vitro

Photobiomodulation effect on local hemoglobin concentration assessed by near-infrared spectroscopy in humans.

LinaresLasers Med Sci2019850nm

positiveHuman

Energy-dependent effect trial of photobiomodulation on blood pressure in hypertensive rats.

De MoraesLasers Med Sci2019660nm

positiveRat

Photobiomodulation induces hypotensive effect in spontaneously hypertensive rats.

BuzinariLasers Med Sci2019660nm

positiveRat

Effect of irradiation with intravascular laser on the hemodynamic variables of hypertensive patients: Study protocol for prospective blinded randomized clinical trial.

IsabellaMedicine (Baltimore)2019

positiveAnimal

Besides Photothermal Effects, Low-Level CO2 Laser Irradiation Can Potentiate Skin Microcirculation Through Photobiomodulation Mechanisms.

ShenPhotobiomodul Photomed Laser Surg201910600nm

unclearHuman

Sustained Release of Growth Factors from Photoactivated Platelet Rich Plasma (PRP).

IrmakEur J Pharm Biopharm2019

positiveIn vitro

Low-level laser therapy as a modifier of erythrocytes morphokinetic parameters in hyperadrenalinemia.

DeryuginaLasers Med Sci2019890nm

positiveRat

Influence of Pulsed He-Ne Laser Irradiation on the Red Blood Cell Interaction Studied by Optical Tweezers.

ZhuMicromachines (Basel)2019633nm

positiveIn vitro

Photobiomodulation (PBM) promotes angiogenesis in-vitro and in chick embryo chorioallantoic membrane model.

WinterSci Rep.2018635nm

positiveIn vitro

Low-Level Light Therapy Protects Red Blood Cells Against Oxidative Stress and Hemolysis During Extracorporeal Circulation.

WalskiFront Physiol2018

positiveAnimal

Effects of light-emitting diodes irradiation on human vascular endothelial cells.

OhInt J Impot Res2018

positiveIn vitro

Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling.

BagheriLasers Med Sci2018675nm

positiveIn vitro

Efficiency of hyperuricemia correction by low level laser therapy in the treatment of arterial hypertension.

KovalenkoWiad Lek.2018635nm

positiveHuman

Cardio-light: nitric oxide uncaged.

Bath & GuptaLasers Med Sci2018

unclearReview

Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light.

KeszlerArch Biochem Biophys2018

positiveMouse

Potentials for Prolonging Shelf-Life of Platelets by Near Infrared Low-Level Light.

ZhangJ Biophotonics2018830nm

positiveIn vitro

In vitro impact of laser irradiation on platelet aggregation.

Shakir & Rasheed NajiLasers Med Sci2018532nm

positiveIn vitro

Adipose-derived stem cell spheroid treated with low-level light irradiation accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia.

ParkCytotherapy2017660nm

positiveMouse

Effect of endovascular coronary low-level laser therapy during angioplasty on the release of endothelin-1 and nitric oxide.

DerkaczAdv Clin Exp Med2017808nm

positiveHuman

The influence of low level laser irradiation on vascular reactivity.

Mackiewicz-MilewskaAdv Med Sci2017810nm

positiveRat

Hypotensive acute effect of photobiomodulation therapy on hypertensive rats.

OishiLife Sci2017660nm

positiveRat

The effect of LED on blood microcirculation during chronic wound healing in diabetic and non-diabetic patients-a prospective, double-blind randomized study.

FrangezLasers Med Sci2017

positiveHuman

Red/Near Infrared Light Stimulates Release of an Endothelium Dependent Vasodilator and Rescues Vascular Dysfunction in a Diabetes Model.

KeszlerFree Radic Biol Med2017670nm

positiveMouse

Low-Level Laser Irradiation Exerts Antiaggregative Effect on Human Platelets Independently on the Nitric Oxide Metabolism and Release of Platelet Activation Markers.

RolaOxid Med Cell Longev2017662nm

positiveIn vitro

Low-power laser irradiation inhibits PDGF-BB-induced migration and proliferation via apoptotic cell death in vascular smooth muscle cells.

BaekLasers Med Sci2017532nm

positiveIn vitro

Effect of the transdermal low-level laser therapy on endothelial function.

SzymczyszynLasers Med Sci2016808nm

positiveHuman

[Impact of low level laser therapy on skin blood flow]. [Article in Polish]

PodogrodzkiDev Period Med2016680nm

positiveHuman

Noninvasive low-level laser therapy for thrombocytopenia.

ZhangSci Transl Med2016810nm

positiveMouse

Low-level light treatment ameliorates immune thrombocytopenia.

YangSci Rep2016830nm

positiveMouse

The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women.

SalgadoLasers Med Sci2015627nm

positiveHuman

Effect of LLLT on endothelial cells culture.

GóralczykLasers Med Sci2015635nm

positiveIn vitro

Vascular regeneration effect of adipose-derived stem cells with light-emitting diode phototherapy in ischemic tissue.

ParkLasers Med Sci2015660nm

positiveMouse

The influence of Multiwave Locked System (MLS) laser therapy on clinical features, microcirculatory abnormalities and selected modulators of angiogenesis in patients with Raynaud's phenomenon.

Kuryliszyn-MoskalClin Rheumatol2015

positiveHuman

The effects of low-intensity He-Ne laser irradiation on erythrocyte metabolism.

LuoLasers Med Sci2015633nm

positiveIn vitro

Near infrared light induces post-translational modifications of human red blood cell proteins

WalskiPhotochem Photobiol Sci2015

positiveIn vitro

Arrest of progression of pre-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by low level laser phototherapy.

GavishLasers Surg Med2014780nm

positiveMouse

Effects of intravascular low-level laser therapy during coronary intervention on selected growth factors levels.

DerkaczPhotomed Laser Surg2014808nm

positiveHuman

Hemodynamic effect of laser therapy in spontaneously hypertensive rats.

TomimuraArq Bras Cardiol2014780nm

positiveRat

Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse.

ZaidiPhotochem Photobiol2013670nm

positiveMouse

Laser and LED phototherapies on angiogenesis.

de SousaLasers Med Sci2013

positiveRat

Effect of the intravascular low energy laser illumination during percutaneous coronary intervention on the inflammatory process in vascular wall.

DerkaczLasers Med Sci2013808nm

positiveHuman

Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb.

LohrJ Mol Cell Cardiol2013670nm

positiveMouse

Effect of low-level laser therapy on blood flow and oxygen- hemoglobin saturation of the foot skin in healthy subjects: a pilot study.

HeuLaser Ther2013660nm

positiveHuman

Phototherapy with low-level laser influences the proliferation of endothelial cells and vascular endothelial growth factor and transforming growth factor-beta secretion.

SzymanskaJ Physiol Pharmacol2013

positiveIn vitro

Influence of low-power laser illumination on pro-inflammatory response in human endothelial cells stimulated with interleukin-1a.

ProtasiewiczIn Vivo2013808nm

positiveIn vitro

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