PBM Research104 studies

Photobiomodulation for Eyes

104 peer-reviewed studies on light therapy for eyes, spanning 1987 to 2020. Filtered from the full PBM database of 4,914 studies.

104

Total Studies

Human Studies

Positive Results

Wavelength Bands

Study Types

Rat

30 (29%)

Human

25 (24%)

Mouse

14 (13%)

Review

13 (13%)

Animal

9 (9%)

Rabbit

7 (7%)

Outcomes

positive

84 (81%)

unclear

16 (15%)

negative

4 (4%)

Wavelength Distribution

Red (600-700nm)

56 studies

Not specified

39 studies

Near-IR (700-900nm)

9 studies

All Studies (104)

Photobiomodulation Mediates Neuroprotection against Blue Light Induced Retinal Photoreceptor Degeneration

HeinigInt J Mol Sci2020

positiveMouse

Safety Profile of Slit-Lamp-Delivered Retinal Laser Photobiomodulation

AoTransl Vis Sci Technol2020670nm

positiveRat

A double-masked, randomized, sham-controlled, single-center study with photobiomodulation for the treatment of dry age-related macular degeneration.

MarkowitzRetina2019

positiveHuman

Improving mitochondrial function significantly reduces the rate of age related photoreceptor loss.

SivapathasuntharamExp Eye Res2019670nm

positiveMouse

Low-power lasers on amblyopia

Paiva & FonsecaLaser Phys Lett2019

unclearReview

Low level light therapy for the treatment of recalcitrant chalazia: a sample case summary.

Stonecipher & PotvinClin Ophthalmol2019

positiveHuman

Enhancement of corneal epithelium cell survival, proliferation and migration by red light: Relevance to corneal wound healing.

Núñez-Álvarez & OsborneExp Eye Res2019

negativeIn vitro

The combined effect of photobiomodulation therapy and chia seeds supplementation for the treatment of diabetic retinopathy in experimental rats

AbdelkawiJ Arab Soc Med Res2019670nm

positiveRat

Effects of Low-level Light Therapy at 740 nm on Dry Eye Disease In Vivo

GooMedical Lasers; Engineering, Basic Research, and Clinical Application2019740nm

positiveMouse

Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction.

StonecipherClin Ophthalmol2019

positiveHuman

Blue light exacerbates and red light counteracts negative insults to retinal ganglion cells in situ and R28 cells in vitro.

Núñez‐ÁlvarezNeurochem Int2019

negativeIn vitro

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light.

Núñez-ÁlvarezActa Ophthalmol2019

positiveIn vitro

Effects of the long wavelength-filtered continuous spectrum on natural refractive development in juvenile guinea pigs.

LiInt J Ophthalmol2019

positiveAnimal

The effect of infra-red light on intraocular pressure.

DimitrovaArq Bras Oftalmol2019

positiveHuman

A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity.

KentPediatr Res2019670nm

positiveHuman

Five-year follow-up of low-level laser therapy (LLLT) in patients with age-related macular degeneration (AMD)

KoevCONFERENCE PAPER: Journal of Physics2018633nm

positiveHuman

Photobiomodulation Inhibits Long-term Structural and Functional Lesions of Diabetic Retinopathy.

ChengDiabetes2018670nm

positiveMouse

Bioptron light therapy to dry eye caused by long-term topically applied antiglaucoma drug with benzalkonium-chloride

BrankovicActa Medica Medianae2018

positiveHuman

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light.

Núñez‐ÁlvarezActa Ophthalmol2018630nm

negativeIn vitro

Make lighting healthier.

Zielinska-Dabkowska KMNature2018

unclearAnimal

670nm light treatment following retinal injury modulates Müller cell gliosis: Evidence from in vivo and in vitro stress models

LuExp Eye Res2018670nm

positiveRat

Effects of Light of Different Spectral Composition on Refractive Development and Retinal Dopamine in Chicks.

WangInvest Ophthalmol Vis Sci2018

positiveAnimal

Narrow-band, long-wavelength lighting promotes hyperopia and retards vision-induced myopia in infant rhesus monkeys.

HungExp Eye Res2018630nm

positiveAnimal

Physical treatments for age-related macular degeneration

WaughBOOK: Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review2018

unclearReview

Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline.

SivapathasuntharamNeurobiol Aging2017670nm

positiveMouse

Near infra-red light attenuates corneal endothelial cell dysfunction in situ and in vitro.

Núñez-ÁlvarezExp Eye Res2017

negativeRat

Photobiomodulation with 670 nm light ameliorates Müller cell-mediated activation of microglia and macrophages in retinal degeneration.

LuExp Eye Res2017670nm

positiveRat

The wavelength composition and temporal modulation of ambient lighting strongly affect refractive development in young tree shrews.

GawneExp Eye Res2017

positiveAnimal

Long-wavelength (red) light produces hyperopia in juvenile and adolescent tree shrews.

GawneVision Res2017

positiveAnimal

Light-Emitting Diode (LED) therapy improves occipital cortex damage by decreasing apoptosis and increasing BDNF-expressing cells in methanol-induced toxicity in rats.

GhanbariBiomed Pharmacother2017670nm

positiveRat

Retinal pigment epithelium in the pathogenesis of age-related macular degeneration and photobiomodulation as a potential therapy?

AoClin Exp Ophthalmol2017

unclearReview

Protective treatments and their target retinal ganglion cells in diabetic retinopathy.

ZhangBrain Res Bull2017

unclearReview

Photostimulation of mitochondria as a treatment for retinal neurodegeneration.

BeirneMitochondrion2017

unclearReview

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age-related macular degeneration.

MerryActa Ophthalmol2016

positiveHuman

Short-term effects of extremely low-frequency pulsed electromagnetic field and pulsed low-level laser therapy on rabbit model of corneal alkali burn.

Rezaei KanaviExp Eye Res2016810nm

positiveRabbit

Efficacy of 670 nm Light Therapy to Protect against Photoreceptor Cell Death Is Dependent on the Severity of Damage

Chu-TanInt J Photoenergy2016670nm

positiveRat

Optical monitoring of retinal respiration in real time: 670 nm light increases the redox state of mitochondria.

KaynezhadExp Eye Res2016670nm

positiveRat

Red Light Treatment in an Axotomy Model of Neurodegeneration.

BeirnePhotochem Photobiol2016670nm

positiveMouse

Red light of the visual spectrum attenuates cell death in culture and retinal ganglion cell death in situ.

Del Olmo-AguadoActa Ophthalmol2016630nm

positiveRat

Targeting mitochondrial function to treat optic neuropathy.

GuevenMitochondrion2016

unclearReview

Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy

RoyAm J Pathol2016

unclearReview

Photobiomodulation for the treatment of retinal diseases: a review.

Geneva (Ivayla)Int J Ophthalmol2016

unclearReview

Near-Infrared Photobiomodulation in Retinal Injury and Disease.

EellsAdv Exp Med Biol2016

unclearReview

Glaucoma: Focus on mitochondria in relation to pathogenesis and neuroprotection.

OsborneEur J Pharmacol2016

unclearReview

Visual light effects on mitochondria: The potential implications in relation to glaucoma.

OsborneMitochondrion2016

unclearReview

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.

CalazaNeurobiol Aging2015670nm

positiveMouse

Photobiomodulation Mitigates Diabetes-Induced Retinopathy by Direct and Indirect Mechanisms: Evidence from Intervention Studies in Pigmented Mice.

SalibaPLoS One2015670nm

positiveMouse

Effects of Photobiomodulation Therapy on Patients with Primary Open Angle Glaucoma: A Pilot Study. [RETRACTED ARTICLE]

Ivandic & IvandicPhotomed Laser Surg2015780nm

positiveHuman

Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells.

FumaMol Vis2015

positiveHuman

The myopia boom.

Dolgin ENature2015

unclearAnimal

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