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PBM Research72 studies

Photobiomodulation for Immunity

72 peer-reviewed studies on light therapy for immunity, spanning 1987 to 2020. Filtered from the full PBM database of 4,914 studies.

72

Total Studies

3

Human Studies

66

Positive Results

5

Wavelength Bands

Study Types

In vitro
46 (64%)
Mouse
11 (15%)
Rat
7 (10%)
Review
3 (4%)
Human
3 (4%)
Rabbit
1 (1%)

Outcomes

positive
66 (92%)
unclear
5 (7%)
negative
1 (1%)

Wavelength Distribution

Not specified

34 studies

Red (600-700nm)

21 studies

Near-IR (700-900nm)

14 studies

IR (900nm+)

2 studies

Blue (<500nm)

1 studies

All Studies (72)

A Comprehensive Analysis of Near-Contact Photobiomodulation Therapy in the Host-Bacteria Interaction Model Using 3D-Printed Modular LED Platform.

KimAdv Biosyst2020
positiveIn vitro

Attenuation of the inflammatory response and polarization of macrophages by photobiomodulation.

LiLasers Med Sci2020810nm
positiveIn vitro

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system.

DolgovaBiomed Opt Express20191270nm
positiveMouse

Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro.

ZhangJ Cell Mol Med2019810nm
positiveIn vitro

Differential expression of inflammatory and anti-inflammatory mediators by M1 and M2 macrophages after photobiomodulation with red or infrared lasers.

de Brito SousaLasers Med Sci2019
positiveIn vitro

Impact of Photobiomodulation and Condition Medium on Mast Cell Counts, Degranulation, and Wound Strength in Infected Skin Wound Healing of Diabetic Rats.

KouhkheilPhotobiomodul Photomed Laser Surg2019890nm
positiveRat

Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects.

FeehanJ Biophotonics2019
positiveIn vitro

The Effect of Red-to-Near-Infrared (R/NIR) Irradiation on Inflammatory Processes

WalskiInt J Radiat Biol2019
unclearReview

Photobiomodulation in the Metabolism of Lipopolysaccharides-exposed Epithelial Cells and Gingival Fibroblasts.

PansaniPhotochem Photobiol2018
positiveIn vitro

Light-Emitting Diode at 460 ± 20 nm Increases the Production of IL-12 and IL-6 in Murine Dendritic Cells.

Carvalho-CostaPhotomed Laser Surg2017460nm
positiveIn vitro

Effects of low-level laser irradiation on human blood lymphocytes in vitro.

Al MusawiLasers Med Sci2017
positiveIn vitro

Aging of lymphoid organs: Can photobiomodulation reverse age-associated thymic involution via stimulation of extrapineal melatonin synthesis and bone marrow stem cells?

Odinokov & HamblinJ Biophotonics2017
unclearReview

Low level laser (LLL) attenuate LPS-induced inflammatory responses in mesenchymal stem cells via the suppression of NF-κB signaling pathway in vitro.

YinPLoS One2017660nm
positiveIn vitro

Photo-enhancement of macrophage phagocytic activity via Rac1-mediated signaling pathway: Implications for bacterial infection.

LuInt J Biochem Cell Biol2016
negativeMouse

Effect of low energy light irradiation by light emitting diode on U937 cells.

SpotoJ Biol Regul Homeost Agents2016880nm
positiveIn vitro

Low-level laser therapy stimulates the oxidative burst in human neutrophils and increases their fungicidal capacity.

CerdeiraJ Biophotonics2016
unclearIn vitro

Photobiomodulation with 660-nm and 780-nm laser on activated J774 macrophage-like cells: Effect on M1 inflammatory markers.

FernandesJ Photochem Photobiol B2015
positiveIn vitro

Enhancement of monoclonal antibody production in CHO cells by exposure to He-Ne laser radiation.

GhalebCytotechnology2014633nm
positiveIn vitro

Low-level laser therapy suppresses the oxidative stress-induced glucocorticoids resistance in U937 cells: relevance to cytokine secretion and histone deacetylase in alveolar macrophages.

SouzaJ Photochem Photobiol B2014
positiveIn vitro

Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages.

SouzaBraz J Phys Ther2014
positiveIn vitro

TRPV Channels in Mast Cells as a Target for Low-Level-Laser Therapy.

WangCells2014
unclearReview

Effects of low-level laser therapy on M1-related cytokine expression in monocytes via histone modification.

ChenMediators Inflamm2014660nm
positiveIn vitro

Modulation of lipopolysaccharide-induced NF-κB signaling pathway by 635 nm irradiation via heat shock protein 27 in human gingival fibroblast cells.

LimPhotochem Photobiol2013635nm
positiveIn vitro

Effect of 635 nm irradiation on high glucose-boosted inflammatory responses in LPS-induced MC3T3-E1 cells.

KwonLasers Med Sci2013635nm
positiveIn vitro

Infrared low-level diode laser on serum chemokine MCP-1 modulation in mice.

FukudaLasers Med Sci2013780nm
positiveMouse

Infrared low-level diode laser on inflammatory process modulation in mice: pro- and anti-inflammatory cytokines.

FukudaLasers Med Sci2013780nm
positiveMouse

Irradiation of light emitting diode at 850nm inhibits T cell-induced cytokine expression.

CheongJ Dermatol Sci2012
positiveIn vitro

Influence of the HPA axis on the inflammatory response in cutaneous wounds with the use of 670-nm laser photobiomodulation.

VilelaJ Photochem Photobiol B2012670nm
positiveRat

Effects of 810-nm laser on murine bone-marrow-derived dendritic cells.

ChenPhotomed Laser Surg2011810nm
positiveIn vitro

Effect of LED red and IR Photobiomodulation in tongue mast cells in Wistar rats: histological study.

de Carvalho MonteiroPhotomed Laser Surg2011
positiveRat

Enhancement of cutaneous immune response to bacterial infection after low-level light therapy with 1072 nm infrared light: a preliminary study.

LeeJ Photochem Photobiol B20111072nm
positiveMouse

Low-level laser therapy associated to N-acetylcysteine lowers macrophage inflammatory protein-2 (MIP-2) mRNA expression and generation of intracellular reactive oxygen species in alveolar macrophages.

de LimaPhotomed Laser Surg2010660nm
positiveIn vitro

Mitochondrial signaling for histamine releases in laser-irradiated RBL-2H3 mast cells.

WuLasers Surg Med2010
positiveIn vitro

Monitoring of the effect of low-intensity laser radiation with constant pulse generation on neutrophil granulocytes in vitro.

DolgushinBull Exp Biol Med2010
positiveIn vitro

Single session to infrared low level diode laser on TNF-alpha and IL-6 cytokines release by mononuclear spleen cells in mice: a pilot study.

FukudaLasers Surg Med2010780nm
positiveMouse

[Loosening of condensed chromatin in human blood lymphocytes exposed to irradiation with a low-energy He-Ne laser]. [Article in Russian]

Manteifel & KaruIzv Akad Nauk Ser Biol2009633nm
positiveIn vitro

The effects of light-emitting diode irradiation at 610 nm and 710 nm on murine T-cell subset populations.

LimPhotomed Laser Surg2009
positiveRat

In vivo effects of low level laser therapy on inducible nitric oxide synthase.

MoriyamaLasers Surg Med2009
positiveMouse

The effects of daily irradiation with polychromatic visible polarized light on human lymphocyte populations.

LimPhotomed Laser Surg2008
positiveHuman

Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression.

GavishLasers Surg Med2008780nm
positiveIn vitro

One mechanism behind led phototherapy for wound healing and skin rejuvenation: key role of the mast cell

CalderheadLaser Ther2008830nm
positiveHuman

The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing COX inhibitors.

LimLasers Surg Med2007635nm
positiveIn vitro

The biological effects of 632.8-nm low energy He-Ne laser on peripheral blood mononuclear cells in vitro.

GulsoyJ Photochem Photobiol B2006633nm
positiveIn vitro

Pro- and anti-inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light.

Zhevago & SamoilovaPhotomed Laser Surg2006
positiveHuman

Effects of low-power laser radiation on mice immunity.

NovoselovaPhotodermatol Photoimmunol Photomed2006633nm
positiveMouse

Visible light affects chemiluminescence of carp (Cyprinus carpio) blood leukocytes.

BelotskyPhotomed Laser Surg2004
positiveIn vitro

Modulation of macrophage structure and function by low level He-Ne laser irradiation.

DubePhotochem Photobiol Sci2003633nm
positiveIn vitro

Mechanism of therapeutic effect of low-intensity infrared laser radiation.

KlebanovBull Exp Biol Med2001
positiveIn vitro

He-Ne laser irradiation protects B-lymphoblasts from UVA-induced DNA damage.

DubeRadiat Environ Biophys2001633nm
positiveIn vitro

Oxidative stress by visible light irradiation suppresses immunoglobulin production in mouse spleen lymphocytes.

MiyazakiBiosci Biotechnol Biochem2001
positiveIn vitro
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