AH
PBM Research143 studies

Photobiomodulation for Joints

143 peer-reviewed studies on light therapy for joints, spanning 1980 to 2020. Filtered from the full PBM database of 4,914 studies.

143

Total Studies

65

Human Studies

126

Positive Results

4

Wavelength Bands

Study Types

Human
65 (45%)
Rat
40 (28%)
Review
12 (8%)
In vitro
9 (6%)
Animal
6 (4%)
Rabbit
6 (4%)

Outcomes

positive
126 (88%)
unclear
16 (11%)
negative
1 (1%)

Wavelength Distribution

Near-IR (700-900nm)

56 studies

Not specified

52 studies

IR (900nm+)

21 studies

Red (600-700nm)

14 studies

All Studies (143)

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes.

SakataJ Clin Med2020910nm
positiveIn vitro

Exercise program combined with electrophysical modalities in subjects with knee osteoarthritis: a randomised, placebo-controlled clinical trial.

de Paula GomesBMC Musculoskelet Disord2020904nm
positiveHuman

The Efficacy of the Comprehensive Use of Naphthalan and Non-Selective Chromotherapy in the Treatment of Patients with Gonarthrosis.

AbramovichDrug Res (Stuttg)2020
positiveHuman

Level of pain, muscle strength and posture: effects of PBM on an exercise program in women with knee osteoarthritis - a randomized controlled trial.

VassãoLasers Med Sci2020808nm
positiveHuman

Effectiveness Of LED Photobiomodulation Therapy On Treatment With Knee Ostearthritis: An Rat Study.

TrevisanAm J Phys Med Rehabil2020850nm
positiveRat

Evaluation of metalloproteinases-2, -9, and -13 post photobiomodulation in mice talocrural joint.

AbduchLasers Med Sci2019830nm
positiveMouse

Efficacy of wIRA in the treatment of sacroiliitis in male patients with ankylosing spondylitis and its effect on serum VEGF levels.

XuJ Orthop Surg Res2019
positiveHuman

Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model

FelizattiLasers Med Sci.2019830nm
positiveRat

Is There a Role for Photobiomodulation in Treating Damaged Articular Cartilage Due to Injury or Degeneration?

Atik & SezginPhotobiomodul Photomed Laser Surg2019
unclearAnimal

Laser photobiomodulation for cartilage defect in animal models of knee osteoarthritis: a systematic review and meta-analysis.

XiangLasers Med Sci2019
unclearReview

Efficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials.

StausholmBMJ Open2019
unclearReview

Photobiomodulation Therapy Partially Restores Cartilage Integrity and Reduces Chronic Pain Behavior in a Rat Model of Osteoarthritis: Involvement of Spinal Glial Modulation.

BalbinotCartilage2019850nm
positiveRat

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats.

YamadaJ Biophotonics2019904nm
positiveRat

Immediate responses of multi-focal low level laser therapy on quadriceps in knee osteoarthritis patients.

LiKaohsiung J Med Sci2019808nm
positiveHuman

Efficacy of high-intensity laser therapy in comparison with conventional physiotherapy and exercise therapy on pain and function of patients with knee osteoarthritis: a randomized controlled trial with 12-week follow up.

NazariLasers Med Sci20191064nm
positiveHuman

Intra-Articular Laser Treatment Plus Platelet Rich Plasma (PRP) Significantly Reduces Pain in Many Patients Who Had Failed Prior PRP Treatment.

ProdromosMedicines (Basel)2019
positiveHuman

Photobiomodulation via a cluster device associated with a physical exercise program in the level of pain and muscle strength in middle-aged and older women with knee osteoarthritis: a randomized placebo-controlled trial.

VassãoLasers Med Sci2019808nm
positiveHuman

Applications of Photobiomodulation Therapy to Musculoskeletal Disorders and Osteoarthritis with Particular Relevance to Canada.

Gendron & HamblinPhotobiomodul Photomed Laser Surg2019
unclearReview

Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis.

NevesLasers Med Sci2019660nm
unclearRat

Modulation of immune response to induced-arthritis by low-level laser therapy.

Dos AnjosJ Biophotonics2018830nm
positiveMouse

Interleukin-10 and collagen type II immunoexpression are modulated by photobiomodulation associated to aerobic and aquatic exercises in an experimental model of osteoarthritis.

AssisLasers Med Sci2018808nm
positiveRat

Low-Level Laser Therapy Prevents Treadmill Exercise-Induced Progression of Arthrogenic Joint Contracture Via Attenuation of Inflammation and Fibrosis in Remobilized Rat Knees.

KaneguchiInflammation2018830nm
positiveRat

Efficacy of Quadriceps Muscle Strengthening Exercises and Infrared Radiation Therapy in the Management of Symptomatic Knee Osteoarthritis in a South- Eastern Nigerian Population: A Randomised Clinical Study

IhegihuAsian Journal of Research in Medical and Pharmaceutical Sciences2018
positiveHuman

The effect of low-level laser therapy and physical exercise on pain, stiffness, function, and spatiotemporal gait variables in subjects with bilateral knee osteoarthritis: a blind randomized clinical trial.

de Matos Brunelli BraghinDisabil Rehabil2018808nm
positiveHuman

Comparative evaluation of the early effects of the low-level laser therapy versus intra-articular steroids on temporomandibular joint acute osteoarthritis in rats: A histochemical, molecular and imaging evaluation.

AbubakrDent Med Probl2018940nm
positiveRat

A randomized blind placebo-controlled trial investigating the effects of photobiomodulation therapy (PBMT) on canine elbow osteoarthritis.

LooneyCan Vet J2018
positiveAnimal

Low-level laser therapy and interferential current in patients with knee osteoarthritis: a randomized controlled trial protocol.

Alqualo-CostaPain Manag2018
positiveAnimal

Incorporation of photobiomodulation therapy into a therapeutic exercise program for knee osteoarthritis: A placebo-controlled, randomized, clinical trial.

de Paula GomesLasers Surg Med2018
positiveHuman

Class IV laser therapy for trapeziometacarpal joint osteoarthritis: Study protocol for a randomized placebo-controlled trial.

Medina-Porqueres & Cantero-TellezPhysiother Res Int2018
positiveAnimal

Can photobiomodulation associated with implantation of mesenchymal adipose-derived stem cells attenuate the expression of MMPs and decrease degradation of type II collagen in an experimental model of osteoarthritis?

StanckerLasers Med Sci2018808nm
positiveRat

Ultrasound plus low-level laser therapy for knee osteoarthritis rehabilitation: a randomized, placebo-controlled trial.

PaolilloRheumatol Int2018808nm
positiveHuman

Efficacy of High-Intensity Laser Therapy in Treating Knee Osteoarthritis: A First Systematic Review.

Wyszyńska & Bal-BocheńskaPhotomed Laser Surg2018
unclearReview

Long-Term Effect of Pulsed Nd:YAG Laser in the Treatment of Children with Juvenile Rheumatoid Arthritis: A Randomized Controlled Trial.

El-ShamyPhotomed Laser Surg20181064nm
positiveHuman

Low-intensity laser therapy efficacy evaluation in mice subjected to acute arthritis condition.

TrawitzkiJ Photochem Photobiol B2017
positiveMouse

Low-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritis.

IssaLasers Med Sci2017
positiveMouse

Apoptosis induced by low-level laser in polymorphonuclear cells of acute joint inflammation: comparative analysis of two energy densities.

Dos AnjosLasers Med Sci2017830nm
positiveRat

Safety and Effectiveness of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis.

RayeganiJ Lasers Med Sci2017
unclearReview

Prolotherapy and Low Level Laser Therapy: A Synergistic Approach to Pain Management in Chronic Osteoarthritis.

Tieppo FrancioAnesth Pain Med2017
unclearReview

Chondroitin sulfate and glucosamine sulfate associated to photobiomodulation prevents degenerative morphological changes in an experimental model of osteoarthritis in rats.

SanchesLasers Med Sci2017808nm
positiveRat

Long-term results of a randomized, controlled, double-blind study of low-level laser therapy before exercises in knee osteoarthritis: laser and exercises in knee osteoarthritis.

AlfredoClin Rehabil2017904nm
positiveHuman

Efficacy of pulsed Nd:YAG laser in the treatment of patients with knee osteoarthritis: a randomized controlled trial.

AlayatLasers Med Sci20171064nm
positiveHuman

Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia.

SLasers Med Sci2017905nm
positiveHuman

Photobiomodulation therapy in the modulation of inflammatory mediators and bradykinin receptors in an experimental model of acute osteoarthritis.

de OliveiraLasers Med Sci2017808nm
positiveRat

Photobiomodulation therapy associated with treadmill training in the oxidative stress in a collagen-induced arthritis model.

Dos SantosLasers Med Sci2017808nm
positiveRat

LLLT for the management of patients with ankylosing spondylitis.

StasinopoulosLasers Med Sci2016820nm
positiveHuman

Efficacy of pulsed high-intensity laser therapy on pain, functional capacity, and gait in children with haemophilic arthropathy.

El-Shamy & AbdelaalDisabil Rehabil2016
positiveHuman

Positive effects of low level laser therapy (LLLT) on Bouchard's and Heberden's osteoarthritis.

BaltzerLasers Surg Med2016
positiveHuman

Effectiveness of High Intensity Laser Therapy for Reduction of Pain in Knee Osteoarthritis.

Angelova & IlievaPain Res Manag20161064nm
positiveHuman

The effects of high intensity laser therapy on pain and function in patients with knee osteoarthritis.

KimJ Phys Ther Sci2016
positiveHuman

Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats.

AssisOsteoarthritis Cartilage2016808nm
positiveRat
Back to Full PBM Database

Related Products

Light Therapy Devices

FDA-cleared PBM devices, clinically reviewed

Continue Exploring

Sauna & Heat Therapy

1,945 studies

Cold Exposure

2,784 studies

Join the Discussion

Connect with others researching photobiomodulation. Share protocols, results, and questions.

How to Use This Site

Learn how products, research, protocols, and community connect across the platform.