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PBM Research91 studies

Photobiomodulation for Oncology

91 peer-reviewed studies on light therapy for oncology, spanning 1991 to 2020. Filtered from the full PBM database of 4,914 studies.

91

Total Studies

8

Human Studies

72

Positive Results

5

Wavelength Bands

Study Types

In vitro
48 (53%)
Mouse
15 (16%)
Review
11 (12%)
Human
8 (9%)
Animal
7 (8%)
Rat
2 (2%)

Outcomes

positive
72 (79%)
unclear
18 (20%)
negative
1 (1%)

Wavelength Distribution

Not specified

48 studies

Red (600-700nm)

25 studies

Near-IR (700-900nm)

14 studies

IR (900nm+)

3 studies

Blue (<500nm)

1 studies

All Studies (91)

Chemotherapy-Induced Peripheral Neuropathy: Causative Agents, Preventative Strategies, and Treatment Approaches.

KachraniJ Pain Palliat Care Pharmacother2020
unclearReview

Photobiomodulation for Side Effects of Cancer Therapy.

BensadounPhotobiomodul Photomed Laser Surg2020
unclearAnimal

LLLT enhance cyclophosphamide induced TRPM2 channel activation in human colon cancer cells.

Guler & OveyBratisl Lek Listy2020
positiveIn vitro

Low-Level Laser Irradiation Modulated Viability of Normal and Tumor Human Lymphocytes In Vitro.

Saghaei BagheriJ Lasers Med Sci2020630nm
positiveIn vitro

Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis.

KhorsandiCancer Cell Int2020660nm
positiveIn vitro

Phototherapy alters the oncogenic metabolic activity of the breast cancer cells.

ShakibaiePhotodiagnosis Photodyn Ther2020
positiveIn vitro

Photobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model.

BaraschSupport Care Cancer2020660nm
positiveMouse

Photobiomodulation safety in cancer patients: in vivo data [in response to S. Sonis’ commentary 'Could the impact of photobiomodulation on tumor response to radiation be affected by tumor heterogeneity?']

Bensadoun & EpsteinSupport Care Cancer2020
unclearAnimal

Use of low-level laser therapy (LLLT) or photobiomodulation (PBM) for the management of the hand-foot syndrome (HSF) or palmo-plantar erythrodysesthesia (PPED) associated with cancer therapy.

LatifyanSupport Care Cancer2019
unclearHuman

Retrospective evaluation of the safety of low-level laser therapy/photobiomodulation in patients with head/neck cancer.

Genot-KlasterskySupport Care Cancer2019630nm
positiveHuman

Tumor safety and side effects of photobiomodulation therapy used for prevention and management of cancer treatment toxicities. A systematic review.

de Pauli PaglioniOral Oncol2019
unclearReview

Is photobiomodulation therapy effective in reducing pain caused by toxicities related to head and neck cancer treatment? A systematic review.

de Pauli PaglioniSupport Care Cancer2019
unclearReview

Photobiomodulation Enhances Cisplatin Cytotoxicity in a Culture Model with Oral Cell Lineages.

DinizPhotochem Photobiol2019660nm
positiveIn vitro

Percutaneous Exposures of volunteers to polychromatic light (480-3400 nm) trigger systemic mechanism of the human myeloma cells growth delay without any effect on bortezomib cytotoxicity in vitro.

KalmykovaLaser Ther2019
positiveIn vitro

Irradiance plays a significant role in photobiomodulation of B16F10 melanoma cells by increasing reactive oxygen species and inhibiting mitochondrial function.

ChenBiomed Opt Express2019
positiveIn vitro

High energy density LED-based photobiomodulation inhibits squamous cell carcinoma progression in co-cultures in vitro.

TakemotoJ Photochem Photobiol B2019660nm
positiveIn vitro

Cellular transformations in near infrared light induced apoptosis in cancer cells revealed by label-free CARS imaging.

LevchenkoJ Biophotonics2019808nm
positiveIn vitro

Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line.

MatsuoKobe J Med Sci2019630nm
positiveIn vitro

Low-level laser irradiation potentiates anticancer activity of p-coumaric acid against human malignant melanoma cells.

KianmehrMelanoma Res2019
positiveIn vitro

Effects of low level laser therapy in cancer cells-a systematic review of the literature.

da SilvaLasers Med Sci2019
unclearIn vitro

Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas.

SilveiraPhotochem Photobiol Sci2019
unclearReview

Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser.

AbuelmakaremBiosensors (Basel)2019660nm
positiveIn vitro

The Effect of Low Intensity Laser Irradiation on Breast Cancer Cells and Breast Cancer Stem Cells

KiroJ Stem Cell Res Dev2019
positiveIn vitro

Could the impact of photobiomodulation on tumor response to radiation be effected by tumor heterogeneity?

Sonis SSupport Care Cancer2019
unclearAnimal

Photobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model.

BaraschSupport Care Cancer2019
positiveMouse

Treatment of Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Recommendations

HouPain Physician2018
unclearReview

Photobiomodulation and Cancer: What Is the Truth?

HamblinPhotomed Laser Surg2018
unclearReview

Photobiomodulation or low-level laser therapy in the management of cancer therapy-induced mucositis, dermatitis and lymphedema.

BensadounCurr Opin Oncol2018
unclearReview

[Cytotoxic Effect of Low-Intensity Infrared Laser Irradiation on Human Melanoma Cells]. [Article in Russian]

AndreevaMol Biol (Mosk)2018835nm
positiveIn vitro

Low-Level Laser Therapy Stimulates Proliferation in Head and Neck Squamous Cell Carcinoma Cells.

BampsFront Oncol2018830nm
positiveIn vitro

Photobiomodulation is associated with a decrease in cell viability and migration in oral squamous cell carcinoma.

SchalchLasers Med Sci2018
positiveIn vitro

High doses of laser phototherapy can increase proliferation in melanoma stromal connective tissue.

FrigoLasers Med Sci2018
positiveMouse

Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line.

KimLasers Med Sci2018635nm
positiveMouse

Polychromatic light (480–3400 nm) similar to the terrestrial solar spectrum without its UV component in post-surgical immunorehabilitation of breast cancer patients

ZhevagoJ Photochem Photobiol B2017
positiveHuman

The role of photobiomodulation therapy in the care of cancer patients: review of the literature

RobijnsBelgian journal of medical oncology2017
unclearReview

Inhibitory effect of blue light emitting diode on migration and invasion of cancer cells.

OhJ Cell Physiol2017450nm
positiveMouse

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells.

DjavidJ Biophotonics2017685nm
positiveIn vitro

Low level laser therapy induces increased viability and proliferation in isolated cancer cells.

KaraCell Prolif20171064nm
positiveIn vitro

Photobiomodulation of breast and cervical cancer stem cells using low-intensity laser irradiation.

KiroTumour Biol2017
unclearReview

Laser photobiomodulation of pro-inflammatory mediators on Walker Tumor 256 induced rats.

PetrellisJ Photochem Photobiol B2017660nm
positiveRat

Low-Level Laser Therapy May Have Cancer Fighting Role.

Hode LPhotomed Laser Surg2016
unclearAnimal

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature.

RobijnsLasers Med Sci2016
unclearReview

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial.

ArgentaGynecol Oncol2016
positiveHuman

Low-Intensity Laser Irradiation at 636 nm Induces Increased Viability and Proliferation in Isolated Lung Cancer Stem Cells.

Crous & AbrahamsePhotomed Laser Surg2016636nm
positiveIn vitro

Safety evaluation of low level light therapy on cancer cells

Jeong, AndrewDISSERTATION (Boston University)2016808nm
positiveIn vitro

Exploring the effects of low-level laser therapy on fibroblasts and tumor cells following gamma radiation exposure.

Ramos SilvaJ Biophotonics2016660nm
positiveIn vitro

In vitro evaluation of low-intensity light radiation on murine melanoma (B16F10) cells.

PeidaeeMed Biol Eng Comput2016
positiveIn vitro

Effects of pre-radiation exposure to LLLT of normal and malignant cells.

BaraschSupport Care Cancer2016633nm
positiveIn vitro

Effects of combination of melatonin and laser irradiation on ovarian cancer cells and endothelial lineage viability.

AkbarzadehLasers Med Sci2016675nm
positiveIn vitro

Polychromatic Light (480-3400 nm) Upregulates Sensitivity of Tumor Cells to Lysis by Natural Killers.

KnyazevPhotomed Laser Surg2016
positiveIn vitro
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