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PBM Research249 studies

Photobiomodulation for Pain

249 peer-reviewed studies on light therapy for pain, spanning 1981 to 2020. Filtered from the full PBM database of 4,914 studies.

249

Total Studies

145

Human Studies

200

Positive Results

4

Wavelength Bands

Study Types

Human
145 (58%)
Rat
39 (16%)
Review
35 (14%)
Mouse
15 (6%)
Animal
11 (4%)
Rabbit
2 (1%)

Outcomes

positive
200 (80%)
unclear
47 (19%)
negative
2 (1%)

Wavelength Distribution

Not specified

105 studies

Near-IR (700-900nm)

74 studies

IR (900nm+)

44 studies

Red (600-700nm)

26 studies

All Studies (249)

Photobiomodulation Therapy is Able to Modulate PGE2 Levels in Patients With Chronic Non-Specific Low Back Pain: A Randomized Placebo-Controlled Trial.

TomazoniLasers Surg Med2020
positiveHuman

Evaluation of the Therapeutic Effect of Low Level Laser in Controlling Low Back Pain: A Randomized Controlled Trial.

KholoosyJ Lasers Med Sci2020808nm
positiveHuman

Photobiomodulation Decreases Hyperalgesia in Complex Regional Pain Syndrome: An Experimental Mouse Model Subjected to Nicotine.

RodriguesLasers Surg Med2020
positiveMouse

The Beneficial Effects of High-Intensity Laser Therapy and Co-Interventions on Musculoskeletal Pain Management: A Systematic Review.

EzzatiJ Lasers Med Sci2020
unclearReview

The Effectiveness of the Polarized Low-Level Laser in the Treatment of Patients With Myofascial Trigger Points in the Trapezius Muscles.

ShahimoridiJ Lasers Med Sci2020755nm
positiveHuman

Photobiomodulation therapy and transcutaneous electrical nerve stimulation on chronic neck pain patients: Study protocol clinical trial (SPIRIT Compliant).

RampazoMedicine (Baltimore)2020
positiveAnimal

Analgesic effect of Photobiomodulation Therapy: An in vitro and in vivo study.

ZupinJ Biophotonics2019
positiveMouse

Comparison of the effects of low-level laser and pulsed and continuous ultrasound on pain and physical disability in chronic non-specific low back pain: a randomized controlled clinical trial.

RubiraAdv Rheumatol2019
positiveHuman

Effect of laser treatment on postural control parameters in patients with chronic nonspecific low back pain: a randomized placebo-controlled trial.

TaradajBraz J Med Biol Res2019
positiveHuman

Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain: Protocol for a randomized placebo-controlled trial.

TomazoniMedicine (Baltimore)2019
unclearAnimal

Photobiomodulation Therapy: A Possible Answer to the Opioid Crisis.

Ross GPhotobiomodul Photomed Laser Surg2019
unclearAnimal

The Use of Laser Therapy for Patients with Fibromyalgia: A Critical Literary Review.

Kisselev & MoskvinJ Lasers Med Sci2019
unclearReview

Acute low-level laser therapy effects on peripheral muscle strength and resistance in patients with fibromyalgia.

Dos SantosLasers Med Sci2019840nm
positiveHuman

Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis

YehPain Physician2019
unclearReview

The effect of high intensity laser therapy in the management of painful calcaneal spur: a double blind, placebo-controlled study.

YesilLasers Med Sci20191064nm
positiveHuman

Parameters and Effects of Photobiomodulation in Plantar Fasciitis: A Meta-Analysis and Systematic Review.

Dos SantosPhotobiomodul Photomed Laser Surg2019
unclearReview

Clinical efficacy of low-level laser therapy in plantar fasciitis: A systematic review and meta-analysis.

WangMedicine (Baltimore)2019
unclearHuman

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light.

KhannaJ Pain2019660nm
positiveRat

Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.

HanPain Med2019685nm
positiveMouse

Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine.

Ferrara-JrLasers Med Sci2019660nm
positiveRat

Effects of a single treatment with two nonthermal laser wavelengths on chronic neck and shoulder pain.

SilvermanMed Devices (Auckl)2019
positiveHuman

A Comparative Study of Low-Level Laser Therapy and Transcutaneous Electrical Nerve Stimulation as an Adjunct to Pharmaceutical Therapy for Myofascial Pain Dysfunction Syndrome: A Randomized Clinical Trial.

MansourianFront Dent2019
positiveHuman

Thermographic evaluation of occlusal splint and low level laser therapy in myofascial pain syndrome.

Altindiş & GüngörmüşComplement Ther Med2019970nm
positiveHuman

Application of oxytocin with low-level laser irradiation suppresses the facilitation of cortical excitability by partial ligation of the infraorbital nerve in rats: An optical imaging study.

NomaBrain Res2019810nm
positiveRat

Low intensity photobiomodulation decreases neuropathic pain in paw ischemia-reperfusion and spared nervus ischiadicus injury experimental models.

PigattoPain Pract2019890nm
positiveMouse

Effect of deep tissue laser therapy treatment on peripheral neuropathic pain in older adults with type 2 diabetes: a pilot randomized clinical trial.

ChatterjeeBMC Geriatr2019
positiveHuman

Raman spectroscopy of dorsal root ganglia from streptozotocin (STZ)-induced diabetic neuropathic rats submitted to photobiomodulation therapy.

VieiraJ Biophotonics2019904nm
positiveRat

Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis.

MicheliSci Rep2019
positiveRat

Photobiomodulation therapy reduces acute pain and inflammation in mice.

PigattoJ Photochem Photobiol B2019660nm
positiveMouse

The Effects of Photobiomodulation Therapy on Post-Surgical Pain.

EzzatiJ Lasers Med Sci2019
unclearReview

Does Low-level Laser Therapy Provide Additional Benefits to Exercise in Patients with Shoulder Musculoskeletal Disorders? A Meta-analysis of Randomised Controlled Trials.

AwotidebeOrtop Traumatol Rehabil2019
unclearReview

Efficacy of high-intensity laser therapy in subacromial impingement syndrome: a three-month follow-up controlled clinical trial.

Aceituno-GómezClin Rehabil20191064nm
positiveHuman

Pain management using photobiomodulation: mechanisms, location, and repeatability quantified by pain threshold and neural biomarkers in mice.

de SousaJ Biophotonics2018810nm
positiveMouse

Laser photobiomodulation is more effective than ultrasound therapy in patients with chronic nonspecific low back pain: a comparative study.

TantawyLasers Med Sci2018808nm
positiveHuman

Comparison of high-intensity laser therapy and combination of transcutaneous nerve stimulation and ultrasound treatment in patients with chronic lumbar radiculopathy: A randomized single-blind study.

KoluPak J Med Sci20181064nm
positiveHuman

Effects of Physical-Agent Pain Relief Modalities for Fibromyalgia Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

HondaPain Res Manag2018
unclearReview

Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial.

Germano MacielLasers Med Sci2018808nm
positiveHuman

Botulinum toxin A (BT-A) versus low-level laser therapy (LLLT) in chronic migraine treatment: a comparison.

LoebArq Neuropsiquiatr2018
positiveHuman

Comparative effectiveness of extracorporeal shock wave, ultrasound, low-level laser therapy, noninvasive interactive neurostimulation, and pulsed radiofrequency treatment for treating plantar fasciitis: A systematic review and network meta-analysis.

LiMedicine (Baltimore)2018
unclearReview

Comparison of effects of low-level laser therapy and extracorporeal shock wave therapy in plantar fasciitis treatment: A randomized, prospective, single-blind clinical study.

Yinilmez SanmakTurk J Phys Med Rehabil2018685nm
positiveHuman

The effect of high-intensity versus low-level laser therapy in the management of plantar fasciitis: a randomized clinical trial.

OrdahanLasers Med Sci2018
positiveHuman

Combination Therapy Versus Exercise and Orthotic Support in the Management of Pain in Plantar Fasciitis: A Randomized Controlled Trial.

CinarFoot Ankle Int2018
positiveHuman

Modulation of exercise-induced muscular damage and hyperalgesia by different 630 nm doses of light-emitting diode therapy (LEDT) in rats.

VasconcelosLasers Med Sci2018630nm
positiveRat

Comparative study of shockwave therapy and low-level laser therapy effects in patients with myofascial pain syndrome of the trapezius.

KirályRheumatol Int2018
positiveHuman

Low-level laser therapy and dry needling for myofascial pain syndrome of the upper trapezius muscle: An interventional study

AgungJ Phys: Conference Series2018
positiveHuman

Optimal Laser Phototherapy Parameters for Pain Relief.

KatePhotomed Laser Surg2018
unclearReview

The Effect of Low-Level Laser on Postoperative Pain After Elective Cesarean Section

PoursalehanAnesth Pain Med2018
positiveHuman

Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial.

LangellaLasers Med Sci2018
positiveHuman

Therapeutic and Analgesic Efficacy of Laser in Conjunction With Pharmaceutical Therapy for Trigeminal Neuralgia.

EbrahimiJ Lasers Med Sci2018810nm
unclearHuman

Light-Emitting Diode Phototherapy Reduces Nocifensive Behavior Induced by Thermal and Chemical Noxious Stimuli in Mice: Evidence for the Involvement of Capsaicin-Sensitive Central Afferent Fibers.

PigattoMol Neurobiol2017890nm
positiveMouse
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