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PBM Research210 studies

Photobiomodulation for Skin

210 peer-reviewed studies on light therapy for skin, spanning 1984 to 2020. Filtered from the full PBM database of 4,914 studies.

210

Total Studies

72

Human Studies

167

Positive Results

6

Wavelength Bands

Study Types

Human
72 (34%)
In vitro
47 (22%)
Rat
29 (14%)
Review
27 (13%)
Mouse
21 (10%)
Animal
12 (6%)

Outcomes

positive
167 (80%)
unclear
38 (18%)
negative
5 (2%)

Wavelength Distribution

Not specified

121 studies

Red (600-700nm)

55 studies

Near-IR (700-900nm)

17 studies

Green (500-600nm)

8 studies

IR (900nm+)

8 studies

Blue (<500nm)

1 studies

All Studies (210)

Light Emitting Diode Phototherapy for Skin Aging.

HuangJ Drugs Dermatol2020
unclearReview

Assessment of Laser Effects on Skin Rejuvenation.

Heidari BeigvandJ Lasers Med Sci2020
unclearReview

Efficacy and Tolerability of Phototherapy With Light-Emitting Diodes for Sensitive Skin: A Pilot Study.

SonbolFront Med (Lausanne)2020630nm
positiveHuman

Fluorescent Light Energy: The Future for Treating Inflammatory Skin Conditions?

EdgeJ Clin Aesthet Dermatol2019
positiveHuman

In vitro effect of low-level laser therapy on the proliferative, apoptosis modulation, and oxi-inflammatory markers of premature-senescent hydrogen peroxide-induced dermal fibroblasts.

MaldanerLasers Med Sci2019660nm
negativeIn vitro

Photobiomodulation Elicits a Differential Cytokine Response in a Cultured Analogue of Human Skin.

PrindezeEplasty2019660nm
positiveIn vitro

Proteomic Analysis Reveals Anti-Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts.

ChangLasers Surg Med2019463nm
positiveIn vitro

MicroRNA expression analysis of human skin fibroblasts treated with high-fluence light-emitting diode-red light.

MamalisJ Biophotonics2019633nm
positiveIn vitro

Preemptive treatment with photobiomodulation therapy in skin flap viability.

MartignagoJ Photochem Photobiol B2019660nm
positiveRat

Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap.

CalisLasers Surg Med2019
positiveRat

Photobiomodulation therapy is able to decrease IL1B gene expression in an in vitro cellular model of hidradenitis suppurativa.

FerriLasers Med Sci2019
positiveIn vitro

Photobiomodulation as potential novel third line tool for non-invasive treatment of Hidradenitis Suppurativa.

TricaricoG Ital Dermatol Venereol2019
unclearReview

Advances in phototherapy for psoriasis and atopic dermatitis.

KeményExpert Rev Clin Immunol2019
unclearReview

The use of lasers and light sources in skin rejuvenation.

Houreld NNClin Dermatol2019
unclearReview

Safety of light emitting diode-red light on human skin: two randomized controlled trials.

JagdeoJ Biophotonics2019
positiveHuman

A single-blind, dose-escalation, phase I study of high-fluence light-emitting diode-red light on Caucasian non-Hispanic skin: study protocol for a randomized controlled trial.

WangTrials2019
unclearAnimal

Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential.

AbePLoS One2019
positiveAnimal

A dose-ranging, parallel group, split-face, single-blind phase II study of light emitting diode-red light (LED-RL) for skin scarring prevention: study protocol for a randomized controlled trial.

NguyenTrials2019
unclearAnimal

Transcriptomic analysis of human dermal fibroblast cells reveals potential mechanisms underlying the protective effects of visible red light against damage from ultraviolet B light.

Hyun SooJ Dermatol Sci2019660nm
positiveIn vitro

Mechanisms of repigmentation induced by photobiomodulation therapy in vitiligo

YuExp Dermatol2019
unclearReview

Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy

HanLasers Med Sci2018
positiveIn vitro

High-Fluence Light-Emitting Diode-Generated Red Light Modulates the Transforming Growth Factor-Beta Pathway in Human Skin Fibroblasts.

Mamalis & JagdeoDermatol Surg2018633nm
positiveIn vitro

Comparison of two different laser photobiomodulation protocols on the viability of random skin flap in rats.

MartignanoLasers Med Sci2018660nm
positiveRat

Effect of 810 nm Near-Infrared Laser on Revascularization of Ischemic Flaps in Rats.

MaPhotomed Laser Surg2018810nm
positiveRat

Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells.

LeongPhotochem Photobiol2018
positiveIn vitro

Effects of red light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects.

FalconePhotodermatol Photoimmunol Photomed2018656nm
positiveHuman

Local and systemic effects of low-level light therapy with light-emitting diodes to improve erythema after fractional ablative skin resurfacing: a controlled study.

WanitphakdeedechaLasers Med Sci2018
positiveHuman

Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes.

ChenJ Dermatol Sci2018585nm
positiveIn vitro

Dual Effect of Photobiomodulation on Melasma: Downregulation of Hyperpigmentation and Enhanced Solar Resistance-A Pilot Study.

Barolet DJ Clin Aesthet Dermatol2018940nm
positiveHuman

Preconditioning With Low-Level Laser Irradiation Enhances the Therapeutic Potential of Human Adipose-derived Stem Cells in a Mouse Model of Photoaged Skin.

LiaoPhotochem Photobiol2018650nm
positiveMouse

Combination of Natural Extracts and Photobiomodulation in Keratinocytes Subjected to UVA Radiation

SilvaPhotochem Photobiol2018640nm
positiveRat

Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser.

QinLasers Med Sci20181064nm
positiveOther

Efficacy of phototherapy to treat facial ageing when using a red versus an amber LED: a protocol for a randomised controlled trial.

Rocha MotaBMJ Open2018
unclearAnimal

Effect of orange polarized light on post burn pediatric scar: a single blind randomized clinical trial

NesreinJ Phys Ther Sci2018
positiveHuman

Red light accelerates the formation of a human dermal equivalent.

OliveiraJ Biomater Appl2018630nm
unclearIn vitro

Clinical comparison of salicylic acid peel and LED-Laser phototherapy for the treatment of Acne vulgaris in teenagers.

AlbaJ Cosmet Laser Ther2017
positiveHuman

Low-level red LED light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne.

LiLasers Surg Med2017637nm
positiveIn vitro

The Combined Effects of Curcumin Administration and 630 nm LED Phototherapy against DNCB-induced Atopic Dermatitis-like Skin Lesions in BALB/c Mice

JekalKorean J Clin Lab Sci2017630nm
positiveMouse

Therapeutic Effects of a Light Emitting Diode at a Variety of Wavelengths on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

ChoAnn Dermatol2017
positiveMouse

Influence of low-level laser on pain and inflammation in type 2 diabetes mellitus with diabetic dermopathy - A case report.

HazariJ Cosmet Laser Ther2017830nm
positiveHuman

Skin reactions after photodynamic therapy are unaffected by 839 nm photobiomodulation therapy: A randomized, double-blind, placebo-controlled, clinical trial.

BayLasers Surg Med2017
positiveHuman

The Combination of Resveratrol and High-Fluence Light Emitting Diode-Red Light Produces Synergistic Photobotanical Inhibition of Fibroblast Proliferation and Collagen Synthesis: A Novel Treatment for Skin Fibrosis.

Mamalis & JagdeoDermatol Surg2017633nm
positiveIn vitro

Near-Infrared Irradiation Increases Length of Axial Pattern Flap Survival in Rats.

YasunagaEplasty2017
positiveRat

Enhanced survival of ischemic skin flap by combined treatment with bone marrow-derived stem cells and low-level light irradiation.

MoonLasers Med Sci2017850nm
positiveMouse

Human adipose-derived stem cell spheroid treated with photobiomodulation irradiation accelerates tissue regeneration in mouse model of skin flap ischemia.

ParkLasers Med Sci2017660nm
positiveMouse

Long-term effects of pulsed high-intensity laser therapy in the treatment of post-burn pruritus: a double-blind, placebo-controlled, randomized study.

EbidLasers Med Sci20171064nm
positiveHuman

Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo.

OhPhotodermatol Photoimmunol Photomed2017660nm
positiveMouse

A Systematic Review of Light Emitting Diode (LED) Phototherapy for Treatment of Psoriasis: An Emerging Therapeutic Modality.

HoJ Drugs Dermatol2017
unclearReview

A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging.

JiangLasers Med Sci2017
positiveHuman

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheek.

Kim & ChoiJ Phys Ther Sci2017
positiveHuman
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